![]() Studies of depression associated with physical conditions and specific subtypes of depression (e.g. Systematic reviews, meta-analyses and large data-set analyses in the following areas were identified: serotonin and serotonin metabolite, 5-HIAA, concentrations in body fluids serotonin 5-HT 1A receptor binding serotonin transporter (SERT) levels measured by imaging or at post-mortem tryptophan depletion studies SERT gene associations and SERT gene-environment interactions. ![]() PubMed, EMBASE and PsycINFO were searched using terms appropriate to each area of research, from their inception until December 2020. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. ![]() ![]() The serotonin hypothesis of depression is still influential. ![]()
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